Yanxin Liu

Assistant Professor

Liu Group

(240) 314-6441 yxliu@umd.edu

Research in Dr. Yanxin Liu's lab focuses on the mechanistic understanding of chaperone-mediated protein folding and translocation. We employ an integrative approach that combines biophysics, biochemistry, structural biology, and computational modeling. In particular, we are specialized in emerging technologies of high-resolution single-particle cryo-electron microscopy, cryo-electron tomography, and large-scale atomistic molecular dynamics simulation. We are currently recruiting undergraduate students, graduate students, and postdoctoral researchers. Please contact Dr. Liu for more details.

Publications

Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin.

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

Designed peptides that assemble into cross-α amyloid-like structures.

Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.

Comparing Fast Pressure Jump and Temperature Jump Protein Folding Experiments and Simulations.

Structural Characterization of λ-Repressor Folding from All-Atom Molecular Dynamics Simulations.

Stabilization of native and non-native structures by salt bridges in a lattice model of the GCN4 leucine dimer.

Sampling of states for estimating the folding funnel entropy and energy landscape of a model alpha-helical hairpin peptide.

Yanxin Liu

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