Publications

Filter Year

Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.
Njar VC, Brodie AM. 2015. Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer. Journal of medicinal chemistry 58(5): 2077-87. DOI: 10.1021/jm501239f
Quantitative residue-specific protein backbone torsion angle dynamics from concerted measurement of 3J couplings.
Lee JH, Li F, Grishaev A, Bax A. 2015. Quantitative residue-specific protein backbone torsion angle dynamics from concerted measurement of 3J couplings. Journal of the American Chemical Society 137(4): 1432-5. DOI: 10.1021/ja512593s
Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I.
Venditti V, Tugarinov V, Schwieters CD, Grishaev A, Clore GM. 2015. Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I. Nature communications 6: 5960. DOI: 10.1038/ncomms6960
Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators.
Guo M, Zheng Y, Terell JL, Ad M, Opoku-Temeng C, Bentley WE, Sintim HO. 2015. Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators. Chemical communications (Cambridge, England) 51(13): 2617-20. DOI: 10.1039/c4cc09361e
Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds.
Porter LL, He Y, Chen Y, Orban J, Bryan PN. 2015. Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds. Biophysical journal 108(1): 154-62. DOI: 10.1016/j.bpj.2014.10.073