Publications

Chemometric Outlier Classification of 2D-NMR Spectra to Enable Higher Order Structure Characterization of Protein Therapeutics.
Sheen DA, Shen VK, Brinson RG, Arbogast LW, Marino JP, Delaglio F, Sheen DA, Shen VK, Brinson RG, Arbogast LW, Marino JP, Delaglio F. 2020. Chemometric Outlier Classification of 2D-NMR Spectra to Enable Higher Order Structure Characterization of Protein Therapeutics. Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society 199: . DOI: 10.1016/j.chemolab.2020.103973
Magnetic Resonance Relaxometry for Determination of Protein Concentration and Aggregation.
Taraban MB, Briggs KT, Yu YB, Taraban MB, Briggs KT, Yu YB. 2020. Magnetic Resonance Relaxometry for Determination of Protein Concentration and Aggregation. Current protocols in protein science 99(1): e102. DOI: 10.1002/cpps.102
The structural basis of T-cell receptor (TCR) activation: An enduring enigma.
Mariuzza RA, Agnihotri P, Orban J, Mariuzza RA, Agnihotri P, Orban J. 2020. The structural basis of T-cell receptor (TCR) activation: An enduring enigma. The Journal of biological chemistry 295(4): 914-925. DOI: 10.1074/jbc.REV119.009411
Microsystems for biofilm characterization and sensing - A review.
Subramanian S, Huiszoon RC, Chu S, Bentley WE, Ghodssi R, Subramanian S, Huiszoon RC, Chu S, Bentley WE, Ghodssi R. 2020. Microsystems for biofilm characterization and sensing - A review. Biofilm 2: 100015. DOI: 10.1016/j.bioflm.2019.100015
Melanin Produced by the Fast-Growing Marine Bacterium Vibrio natriegens through Heterologous Biosynthesis: Characterization and Application.
Wang Z, Tschirhart T, Schultzhaus Z, Kelly EE, Chen A, Oh E, Nag O, Glaser ER, Kim E, Lloyd PF, et al. 2020. Melanin Produced by the Fast-Growing Marine Bacterium Vibrio natriegens through Heterologous Biosynthesis: Characterization and Application. Applied and environmental microbiology 86(5): . DOI: 10.1128/AEM.02749-19
Redox Activities of Melanins Investigated by Electrochemical Reverse Engineering: Implications for their Roles in Oxidative Stress.
Kim E, Panzella L, Napolitano A, Payne GF, Kim E, Panzella L, Napolitano A, Payne GF. 2020. Redox Activities of Melanins Investigated by Electrochemical Reverse Engineering: Implications for their Roles in Oxidative Stress. The Journal of investigative dermatology 140(3): 537-543. DOI: 10.1016/j.jid.2019.09.010
Tethered molecular redox capacitors for nanoconfinement-assisted electrochemical signal amplification.
Kang M, Mun C, Jung HS, Ansah IB, Kim E, Yang H, Payne GF, Kim DH, Park SG, Kang M, Mun C, Jung HS, Ansah IB, Kim E, Yang H, Payne GF, Kim DH, Park SG. 2020. Tethered molecular redox capacitors for nanoconfinement-assisted electrochemical signal amplification. Nanoscale 12(6): 3668-3676. DOI: 10.1039/c9nr08136d
Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation.
Austin JW, Buckner CM, Kardava L, Wang W, Zhang X, Melson VA, Swanson RG, Martins AJ, Zhou JQ, Hoehn KB, et al. 2019. Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation. Science translational medicine 11(520): . DOI: 10.1126/scitranslmed.aax0904
Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity.
Yang H, Luo D, Etobayeva I, Li X, Gong Y, Wang S, Li Q, Xu P, Yin W, He J, et al. 2020. Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity. Antimicrobial agents and chemotherapy 64(2): . DOI: 10.1128/AAC.01610-19
Protein-loaded soluble and nanoparticulate formulations of ionic polyphosphazenes and their interactions on molecular and cellular levels.
Andrianov AK, Marin A, Deng J, Fuerst TR, Andrianov AK, Marin A, Deng J, Fuerst TR. 2020. Protein-loaded soluble and nanoparticulate formulations of ionic polyphosphazenes and their interactions on molecular and cellular levels. Materials science & engineering. C, Materials for biological applications 106: 110179. DOI: 10.1016/j.msec.2019.110179
Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
Pidugu LS, Dai Q, Malik SS, Pozharski E, Drohat AC, Pidugu LS, Dai Q, Malik SS, Pozharski E, Drohat AC. 2019. Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase. Journal of the American Chemical Society 141(47): 18851-18861. DOI: 10.1021/jacs.9b10376
Strategies for Development of a Next-Generation Protein Sequencing Platform.
Callahan N, Tullman J, Kelman Z, Marino J, Callahan N, Tullman J, Kelman Z, Marino J. 2020. Strategies for Development of a Next-Generation Protein Sequencing Platform. Trends in biochemical sciences 45(1): 76-89. DOI: 10.1016/j.tibs.2019.09.005
Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge.
Pal LR, Kundu K, Yin Y, Moult J, Pal LR, Kundu K, Yin Y, Moult J. 2020. Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge. Human mutation 41(2): 347-362. DOI: 10.1002/humu.23933
Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.
Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, et al. 2019. Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo. Cancers 11(11): . DOI: 10.3390/cancers11111637
Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Gallagher DT, McCullough C, Brinson RG, Ahn J, Marino JP, Dimasi N, Gallagher DT, McCullough C, Brinson RG, Ahn J, Marino JP, Dimasi N. 2019. Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions. Pharmaceutics 11(10): . DOI: 10.3390/pharmaceutics11100546
The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.
Comert F, Greenwood A, Maramba J, Acevedo R, Lucas L, Kulasinghe T, Cairns LS, Wen Y, Fu R, Hammer J, et al. 2019. The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels. The Journal of biological chemistry 294(49): 18557-18570. DOI: 10.1074/jbc.RA119.010232
Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment.
Lensink MF, Brysbaert G, Nadzirin N, Velankar S, Chaleil RAG, Gerguri T, Bates PA, Laine E, Carbone A, Grudinin S, et al. 2019. Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment. Proteins 87(12): 1200-1221. DOI: 10.1002/prot.25838
Characterization of the internal translation initiation region in monoclonal antibodies expressed in Escherichia coli.
Leith EM, O'Dell WB, Ke N, McClung C, Berkmen M, Bergonzo C, Brinson RG, Kelman Z, Leith EM, O'Dell WB, Ke N, McClung C, Berkmen M, Bergonzo C, Brinson RG, Kelman Z. 2019. Characterization of the internal translation initiation region in monoclonal antibodies expressed in <i>Escherichia coli</i>. The Journal of biological chemistry 294(48): 18046-18056. DOI: 10.1074/jbc.RA119.011008
Critical assessment of methods of protein structure prediction (CASP)-Round XIII.
Kryshtafovych A, Schwede T, Topf M, Fidelis K, Moult J, Kryshtafovych A, Schwede T, Topf M, Fidelis K, Moult J. 2019. Critical assessment of methods of protein structure prediction (CASP)-Round XIII. Proteins 87(12): 1011-1020. DOI: 10.1002/prot.25823
Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.
Singh NK, Abualrous ET, Ayres CM, Noé F, Gowthaman R, Pierce BG, Baker BM, Singh NK, Abualrous ET, Ayres CM, Noé F, Gowthaman R, Pierce BG, Baker BM. 2020. Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen. Proteins 88(3): 503-513. DOI: 10.1002/prot.25829