Pierce Lab Awarded $1.5M from NIH to Model and Design Antibodies and T Cell Receptors
Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) recently received $1.5M from the NIH for their project entitled, “High Resolution Modeling and Design of Immune Recognition.” Dr. Brian Pierce, IBBR Fellow, Assistant Professor in the Department of Cell Biology & Molecular Genetics at University of Maryland, College Park,...
IBBR Researchers Discover Ribosome from the Human Parasite Giardia lamblia May Provide Promising Therapeutic Target in Combating Giardiasis
Giardiasis is an acute human diarrheal disease caused by the microscopic parasite Giardia lamblia (GL) that persists in the environment and causes much suffering when ingested through contaminated water and food. Giardiasis also increases the probability of developing irritable bowel syndrome later in life. New strategies to combat Giardiasis need...
IBBR at Maryland Day!
On Saturday, April 30th Maryland Day returned to College Park with 65,000 visitors! Thanks to the wonderful efforts of our faculty, postdocs, and staff (and a dose of beautiful weather!) IBBR’s presence was a huge success with a steady flow of visitors of all ages! Our booth was located inside...
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Monday, May 23, 2022 - 11:00am
Kyle Anderson (.07)/Kat Yandrofski (.03)
Tuesday, May 24, 2022 - 11:00am
King's College London
Tuesday, June 7, 2022 - 11:00am
Metallated Anticancer Peptides: An Expanded Mechanism that Encompasses Physical and Chemical Bilayer Disruption.
In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their...
In Silico Identification of a β2 Adrenergic Receptor Allosteric Site that Selectively Augments Canonical β2 AR-Gs Signaling and Function.
OBJECTIVE & HYPOTHESIS
Activation of β2 -adrenergic receptors (β2 ARs) leads to airway smooth muscle (ASM) relaxation and bronchodilation. While this facilitates β2 ARs agonists (β-agonists) as...
Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Cancer stem cells (CSCs) virtually present in all tumors albeit in small numbers are primarily responsible for driving cancer progression, metastasis, drug resistance, and recurrence. Prostate...
Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs.
Therapeutic monoclonal antibodies (mAbs) contain a variety of amino acids that are susceptible to enzymatic, chemical, and physical modifications. These modifications can happen throughout...
Conformational Heterogeneity of UCAAUC RNA Oligonucleotide from Molecular Dynamics Simulations, SAXS, and NMR experiments.
We describe the conformational ensemble of the single-stranded r(UCAAUC) oligonucleotide obtained using extensive molecular dynamics (MD) simulations and ROSETTA's FARFAR2 algorithm. The...