• Excellence in Research...
    IBBR scientists lead ground-breaking research, technology development and standards programs that advance and support the fields of biotechnology, biomanufacturing and human health.
  • State-of-the-Art Methods...
    IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
  • Fostering Collaboration...
    IBBR supports a dynamic research environment that facilitates interactions and collaborations between our scientists, partners, and stakeholders; promoting new research directions that complement and build on existing strengths.

Institute for Bioscience and Biotechnology Research Receives $16.8 M Investment from the National Institute of Standards and Technology

New Cooperative Agreement to Aid in the Development of Therapeutics and Vaccines, Improve Access to Medication The Institute for Bioscience and Biotechnology Research (IBBR) announces a newly funded five-year cooperative agreement with the National Institute of Standards and Technology (NIST) headed by the Co-Directors of IBBR, Dr. David J. Weber (PI)...

NIST-IBBR Researchers Awarded Department of Commerce Silver Medal for Developing and Accelerating Industry-Adoption of Structural Methods for Biopharmaceutical Characterization

NIST-IBBR scientists shared in a 2021 Department of Commerce (DOC) Silver Medal Award, the second highest honorary award bestowed by the United States Department of Commerce.  Kyle Anderson, Luke Arbogast, Robert Brinson, Frank Delaglio, Jeffrey Hudgens and John P. Marino were recognized with their NIST colleagues Ryan Evans and Anthony Kearsley for...

European Patent for Method to Detect Protein Aggregation in a Biopharmaceutical Product Granted to IBBR Investigator Bruce Yu and Coworkers

Dr. Katharine Briggs (left), Dr. Bruce Yu (center) and Dr. Marc Taraban (right) in September 2019, shortly after they relocated from the University of Maryland, Baltimore campus to IBBR/USG. Photo Credit: Katharine BriggsFebruary 26th 2021 – A European patent has been granted by the European Patent Office (EPO) for an...

About IBBR

IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.

IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.

IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.

IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.

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IBBR Commons

Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.

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IBBR Postdoc Program

The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.

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NMRPipe

IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.

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285
Current Members
147
Post-Docs Mentored
1073
Publications

Upcoming Events

NIST BMD Seminar: Parathyroid hormone: from the great Indian rhinoceros to LCMS/MS

Etienne Cavalier

Royal Belgian Society of Laboratory Medicine/University of Liege

Tuesday, January 25, 2022 - 10:00am

NIST BMD/IBBR Staff Seminar

Douglas Slotta (.04) and Will Valiant (.06)

Tuesday, February 1, 2022 - 11:00am

NIST BMD/IBBR Staff Seminar

Ella Mihailescu (.03) and Kristen Steffens (.07)

Tuesday, February 8, 2022 - 11:00am

Recent Publications

Computational and Experimental Characterization of rDNA and rRNA G-Quadruplexes.

DNA G-quadruplexes in human telomeres and gene promoters are being extensively studied for their role in controlling the growth of cancer cells. G-quadruplexes have been unambiguously shown to...

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.

T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory responses. Whereas extensive structural information is available on neutralizing antibodies against SARS-CoV-2, such...

Cationic Fluoropolyphosphazenes: Synthesis and Assembly with Heparin as a Pathway to Hemocompatible Nanocoatings.

The development of state-of-the-art blood-contacting devices can be advanced through integrating hemocompatibility, durability, and anticoagulant functionalities within engineered nanoscale...

Circular Dichroism Spectral Similarity Plots to Extend Validation and Correction to All Measured Wavelengths.

Interlaboratory comparisons of circular dichroism (CD) spectra are useful for developing confidence in the measurements associated with optically active molecules. These measurements also help...

Solution Structures of Bacillus anthracis Protective Antigen Proteins Using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics.

We are studying the structures of bacterial toxins that form ion channels and enable macromolecule transport across membranes. For example, the crystal structure of the Staphylococcus aureus...