In vivo Biology and Drug Testing

In Vivo Biology & Drug Testing (IVBDT)

The IVBDT program, directed by Dr. Danna B. Zimmer, Associate Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, aids investigators with the selection of animal models and pharmacodynamic/pharmacokinetic parameters, including route of administration, schedule, dose, volume of distribution, half-life and biological endpoints, for in vivo studies. 


Animal Models

  • Neurological diseases (Alzheimer’s disease) 
  • Cancer (Melanoma) 
  • Signal transduction pathways (Ca2+ signaling) 
  • De novo generation of new animal models for human diseases (transgenic and gene-targeted) 
  • Colony management and animal husbandry 
  • Aseptic non-surgical and sterile surgical procedures 
  • Genotyping (Southern blot and PCR) 

Cell-Based Pharmacokinetics/Pharmacodynamics

  • Cell permeability 
  • Toxicity (LD50) 
  • RNA/miRNA expression 
  • Protein expression, localization, modification and interactions 
  • Subcellular organization 
  • Generation of genetically modified cell lines 

In Vivo Pharmacokinetics

  • Bioavailablity 
  • Distribution 
  • Metabolism 
  • Maximum tolerated dose (MTD) 

In Vivo Pharmcodynamics

  • Behavior testing 
  • Systemic health monitoring 
  • Anatomical and histological pathology 
  • RNA/miRNA expression and distribution 
  • Protein expression, distribution, modification and interactions 


Danna Zimmer, PhD 
9600 Gudelsky Drive
Rockville, MD 20850