News Stories
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Breakthrough Study Advances Quest for a First Hepatitis C Vaccine
A collaborative team of scientists, including researchers from the Institute for Bioscience and Biotechnology Research (IBBR), has made significant strides in uncovering new insights that could help the development of an effective vaccine against Hepatitis C (HCV). HCV is a serious viral infection known as the “silent epidemic” that can...
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Edward Eisenstein Named Fellow of the American Association for the Advancement of Science (AAAS)
Dr. Edward Eisenstein, IBBR Fellow and Associate Professor in the University of Maryland Department of Bioengineering, has been elected a Fellow of the American Association for the Advancement of Science (AAAS), one of the most distinguished honors in the scientific community, recognizing leaders whose work advances science and society. He...
Structural Immunology Studies Reveal New Insights into Viral Immunity and Vaccine Design
Two recent studies from teams including IBBR researchers and collaborators, published in Nature Communications, demonstrate how structural immunology is advancing our understanding of viral immunity and guiding vaccine design. T cells are critical to the body’s immune system and can identify and destroy infected cells by recognizing epitopes, small viral...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: Carol Post, Purdue
NIST Group Meeting; Will Siegall
Seminar: Chunyu Wu, Merck
Recent Publications
The scientific legacy of Martin Karplus from the perspective of his collaborators.
The work of Martin Karplus, who passed away on Dec 28 2024, was at the forefront of computational chemistry and molecular biophysics for a period of more than sixty years. His career started with...
The Role of the TG2-GPR56 Complex in Cutaneous Squamous Cell Carcinoma (CSCC) Aggression and Therapeutic Resistance.
Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent skin cancer diagnosed worldwide after basal cell carcinoma. CSCC represents a growing global public health challenge due to...
Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response.
Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite...
Improved VSV-Ebola-GP booster vaccination approach promotes antibody affinity maturation and durable anti-Ebola immunity in humans.
Short-term boosting of the currently licensed rVSV∆G-ZEBOV-GP vaccine does not generate lasting antibody respones to Ebola virus (EBOV), prompting interest in strategies that elicit more durable...
Engineered subtilisin protease degrades active KRAS in cancer cells, leading to differential cell targeting.
Controlling aberrant RAS signaling has been the subject of intensive efforts aimed at developing specific RAS inhibitors, small molecules that promote RAS degradation, and monobodies that inhibit...