NIST, IBBR Researchers Explore Excipient-Influenced mAb Dynamics at Atomic Resolution
Monoclonal antibodies (mAbs) are now widely used as a platform for the development of therapeutic drugs, due to their many advantages. mAb drugs are protein molecules that fold into three dimensional structures which give these molecules their distinct conformations or shapes. The totality of the elements that contribute to the...
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UMD Postdoc Featured in Pharmtech on Biopharmaceutical Drug Development and Manufacturing
UMD Postdoc Anupreet Kaur, working under the direction of Dr. Robert Brinson, was recently featured in a story by PharmTech covering biopharmaceutical development and manufacturing. In the interview, Kaur highlighted how molecular and cellular biology, particularly a deeper, comprehensive understanding of monoclonal antibodies (mAbs) and antigens are revolutionizing the field...
Frank Delaglio Receives 2024 ACS Division of Analytical Chemistry Chemical Instrumentation Award
Frank Delaglio, of the NIST Biomolecular Measurement Division and Institute for Bioscience and Biotechnology Research (IBBR), was awarded the 2024 American Chemical Society Division of Analytical Chemistry Chemical Instrumentation Award. The award honors Dr. Delaglio as a recognized leader in NMR signal processing and computational NMR, creator of the most...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
BMD Staff Seminar R. Andiramaharavo/ S. Riman, .04/.06
R. Andiramaharavo/ S. Riman, .04/.06
Tuesday, October 22, 2024 - 11:00am
NIST Group Meeting; Jaekyun Jeon
Wednesday, October 23, 2024 - 11:00am
Special Seminar: "Analytical Characterization of Biotherapeutic Products"
Anurag S. Rathore, Ph. D.
Department of Chemical Engineering Indian Institute of Technology, Delhi
Thursday, October 24, 2024 - 11:00am
Recent Publications
Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy.
We present a revised version of the Drude polarizable carbohydrate force field (FF), focusing on refining the ring and exocyclic torsional parameters for hexopyranose monosaccharides. This...
Exploring the potential of structure-based deep learning approaches for T cell receptor design.
Deep learning methods, trained on the increasing set of available protein 3D structures and sequences, have substantially impacted the protein modeling and design field. These advancements have...
Exploring Druggable Binding Sites on the Class A GPCRs Using the Residue Interaction Network and Site Identification by Ligand Competitive Saturation.
G protein-coupled receptors (GPCRs) play a central role in cellular signaling and are linked to many diseases. Accordingly, computational methods to explore potential allosteric sites for this...
TCR3d 2.0: expanding the T cell receptor structure database with new structures, tools and interactions.
Recognition of antigens by T cell receptors (TCRs) is a key component of adaptive immunity. Understanding the structures of these TCR interactions provides major insights into immune protection...
Hydrolytically Degradable Zwitterionic Polyphosphazene Containing HEPES Moieties as Side Groups.
Zwitterionic polymers, ampholytic macromolecules containing ionic moieties of opposite sign on the same pendant groups, exhibit strong protein-repulsive properties and an inherent biological...