News Stories
$1.9 Million NIH Award Renewal Advances AI-Driven Immunology Research at IBBR
IBBR Fellow and UMD Department of Cell Biology and Molecular Genetics Associate Professor Dr. Brian Pierce has received a renewal of his NIH Maximizing Investigators' Research Award (MIRA), award number 2R35GM144083. The renewed award will support the project "Algorithms and Resources for High-Resolution Modeling and Design of Immune Receptor Recognition,"...
Register TODAY for the 5th Annual Early Career Symposium at IBBR
The Institute for Bioscience and Biotechnology Research (IBBR) invites you to participate in the Fifth Annual Early Career Symposium at IBBR on September 16, 2026 from 8:30am-5:00pm at our facility in Rockville, Maryland. This year's symposium builds on the success of our past symposiums which were attended by 150 participants...
UMD Selected for $17.3M NSF Award to Establish Autonomous Biomanufacturing Laboratory
The University of Maryland will launch a new Collaborative for the Realization of Autonomous Biomanufacturing (CRAB) Lab, a remotely accessible, artificial intelligence (AI)-enabled test bed for users from across the U.S. to program automated workflows that design, execute and analyze biomanufacturing experiments. The lab is funded by a four-year $17.3...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
IBBR Fellows Nomination Seminar (Puru Puranik)
IBBR Fellows Nomination Seminar (Hussain Dahodwala)
Seminar: Asher Williams, Columbia University
Recent Publications
Structure of an inhibitor bound to the catalytically important divalent metal ion site of afRioK1.
Rio Kinase 1 (RioK1) is an anti-cancer target for colorectal cancer. In pursuit of selective inhibitors of RioK1, small drug-like molecules were identified using computer-aided drug design (CADD)....
Directed Evolution of the Bacteriophage Endolysin PlyC Reveals a Charge-Mediated Mechanism of Thermal Stabilization.
Bacteriophage endolysins are peptidoglycan hydrolases currently being clinically developed as antibacterial therapeutics. Despite possessing several advantageous antibacterial properties, many...
The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages.
The bridging domain (BD) region on hepatitis C virus (HCV) E1E2 glycoprotein complex is a conserved, E1-dependent conformational site of vulnerability formed by E2 residues 646-704. Given its...
The PtARF6/PtARF8-PtGH3.1 transcriptional module regulates auxin homeostasis and dwarfism in citrus.
Dwarfing rootstocks are crucial for high-density and labor-efficient citrus cultivation, yet the molecular mechanisms underlying plant height regulation remain poorly understood. Using an...
PtWRKY20 negatively regulates salt tolerance in citrus rootstock Poncirus trifoliata.
Salt stress severely limits global crop productivity. Poncirus trifoliata, a widely used citrus rootstock valued for its disease resistance, exhibits sensitivity to salt stress, presenting a major...