News Releases

IBBR Research Discovery Could Be Crucial to Development of Cross-Species Ebola Vaccines and Treatments
Artist rendering:  Ebola virus

The recent cases of Ebola virus infection in the Democratic Republic of the Congo are an alarming reminder of the images and statistics that brought the disease to the forefront of public concern during the 2014 outbreak in West Africa.

IBBR Receives $1.2M NIH Award to Develop 3D Modeling Tool That Could Lead to New Immunotherapies
DMF5 TCR, shown in complex with  its target, has been in clinical trials for melanoma immunotherapy.  Pierce and collaborators redesigned this TCR  to improve its tumor targeting.

New computational tool supports the engineering and development of cancer immunotherapies

Harnessing Viral Enzymes to Combat Bacterial Infections in Dairy Cows

When most of us think about viruses and bacteria, we envision germs that make people sick. But, Dr. Daniel Nelson, IBBR Fellow and Associate Professor, Department of Veterinary Medicine at the University of Maryland College Park, studies viruses that may end up making us well -- by killing disease-causing bacteria.

IBBR Doctoral Candidate, Tsega Solomon, Travels to Dublin to Present Protein Folding Research

Tsega Solomon, a doctoral candidate in Dr. John Orban’s laboratory at the Institute for Bioscience and Biotechnology Research (IBBR), attended the XXVIII International Conference on Magnetic Resonance in Biological Systems, ICMRBS, at the University College Dublin, Dublin, Ireland, on August 19-24, 2018.

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Orban Presents at Gordon Conference in Switzerland

IBBR Fellow Dr. John Orban spoke at the Intrinsically Disordered Proteins Gordon Research Conference held in Les Diablerets, Switzerland in early July.

Montgomery County Students Gain Biotechnology Experience at IBBR
From left:  Melody Zeng, Walter Johnson High School; Vasha Iyer,
IBBR Researcher, Dr. Alexander Andrianov, Receives Funding for Two Collaborations

Collaborations will explore using two novel types of biofunctional synthetic macromolecules of the polyphosphazene (PPZ) family for exciting and very different applications. In the first, PPZs will be developed for use as biocompatible and drug-releasing hydrophobic coatings for indwelling medical devices.

New Cell Lines Will Facilitate Optimized Production of Antibody-based Therapeutics
Image of NISTmAb using surface rendering for the 4 chains and small bright sticks for the variable glycans.  The model was assembled from separate crystal structures for the three lobes and the central hinge region. 
IBBR Researchers Develop Web Platform for Modeling Structure of Immune System Proteins
Summary of the TCRmodel server, where TCR sequences input by users proceed through steps of template-based modeling and refinement, resulting in 3D structural models.

Immune system proteins called T cell receptors (TCRs) are involved in fighting infectious disease and are implicated in a number of autoimmune diseases, such as diabetes and multiple sclerosis.

University of Maryland Student Experiment Returns from Space

University of Maryland undergraduates Rushi Challa and Natalie Ivanina learned techniques and optimized their experiment for space conditions with the help of IBBR Fellow Daniel Nelson and his lab group.  Read more at:  https://cmns.umd.edu/news-events/features/4187