Publications
Crystal Structure of a Bivalent Antibody Fab Fragment.
Shahid S, Gao M, Travis Gallagher D, Pozharski E, Brinson RG, Keck ZY, Foung SKH, Fuerst TR, Mariuzza RA, Shahid S, Gao M, Travis Gallagher D, Pozharski E, Brinson RG, Keck ZY, Foung SKH, Fuerst TR, Mariuzza RA. 2021. Crystal Structure of a Bivalent Antibody Fab Fragment. Journal of molecular biology 433(2): 166714. DOI: 10.1016/j.jmb.2020.11.013
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.
Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, et al. 2020. Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. Cancers 12(11): . DOI: 10.3390/cancers12113412
Quantitative Proteomic Analysis of Biogenesis-Based Classification for Extracellular Vesicles.
Zhang L, Parot J, Hackley VA, Turko IV, Zhang L, Parot J, Hackley VA, Turko IV. 2020. Quantitative Proteomic Analysis of Biogenesis-Based Classification for Extracellular Vesicles. Proteomes 8(4): . DOI: 10.3390/proteomes8040033
COVID-19 reopening strategies at the county level in the face of uncertainty: Multiple Models for Outbreak Decision Support.
Shea K, Borchering RK, Probert WJM, Howerton E, Bogich TL, Li S, van Panhuis WG, Viboud C, Aguás R, Belov A, et al. 2020. COVID-19 reopening strategies at the county level in the face of uncertainty: Multiple Models for Outbreak Decision Support. medRxiv : the preprint server for health sciences : . DOI: 10.1101/2020.11.03.20225409
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, et al. 2020. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science (New York, N.Y.) 370(6523): 1473-1479. DOI: 10.1126/science.abe3255
Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs).
He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J, He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J. 2020. Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs). Journal of molecular biology 432(24): 166697. DOI: 10.1016/j.jmb.2020.10.031
Conformational gating, dynamics and allostery in human monoacylglycerol lipase.
Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, et al. 2020. Conformational gating, dynamics and allostery in human monoacylglycerol lipase. Scientific reports 10(1): 18531. DOI: 10.1038/s41598-020-75497-5
Redox Electrochemistry to Interrogate and Control Biomolecular Communication.
VanArsdale E, Pitzer J, Payne GF, Bentley WE, VanArsdale E, Pitzer J, Payne GF, Bentley WE. 2020. Redox Electrochemistry to Interrogate and Control Biomolecular Communication. iScience 23(9): 101545. DOI: 10.1016/j.isci.2020.101545
ANNEXIN 8 negatively regulates RPW8.1-mediated cell death and disease resistance in Arabidopsis.
Zhao ZX, Xu YJ, Lei Y, Li Q, Zhao JQ, Li Y, Fan J, Xiao S, Wang WM, Zhao ZX, Xu YJ, Lei Y, Li Q, Zhao JQ, Li Y, Fan J, Xiao S, Wang WM. 2021. ANNEXIN 8 negatively regulates RPW8.1-mediated cell death and disease resistance in Arabidopsis. Journal of integrative plant biology 63(2): 378-392. DOI: 10.1111/jipb.13025
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, et al. 2020. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 370(6521): . DOI: 10.1126/science.abe9403
1HN, 13C, and 15N resonance assignments of the Clostridioides difficile receptor binding domain 2 (CDTb, residues 757-876).
Cook ME, Varney KM, Godoy-Ruiz R, Weber DJ, Cook ME, Varney KM, Godoy-Ruiz R, Weber DJ. 2021. 1HN, 13C, and 15N resonance assignments of the Clostridioides difficile receptor binding domain 2 (CDTb, residues 757-876). Biomolecular NMR assignments 15(1): 35-39. DOI: 10.1007/s12104-020-09979-y
Characterization of the Bacteriophage-Derived Endolysins PlySs2 and PlySs9 with In Vitro Lytic Activity against Bovine Mastitis Streptococcus uberis.
Vander Elst N, Linden SB, Lavigne R, Meyer E, Briers Y, Nelson DC, Vander Elst N, Linden SB, Lavigne R, Meyer E, Briers Y, Nelson DC. 2020. Characterization of the Bacteriophage-Derived Endolysins PlySs2 and PlySs9 with In Vitro Lytic Activity against Bovine Mastitis <i>Streptococcus uberis</i>. Antibiotics (Basel, Switzerland) 9(9): . DOI: 10.3390/antibiotics9090621
Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7.
Greenfield J, Shang X, Luo H, Zhou Y, Linden SB, Heselpoth RD, Leiman PG, Nelson DC, Herzberg O, Greenfield J, Shang X, Luo H, Zhou Y, Linden SB, Heselpoth RD, Leiman PG, Nelson DC, Herzberg O. 2020. Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. Scientific reports 10(1): 15402. DOI: 10.1038/s41598-020-72373-0
A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer.
Mohanty A, Nam A, Pozhitkov A, Yang L, Srivastava S, Nathan A, Wu X, Mambetsariev I, Nelson M, Subbalakshmi AR, et al. 2020. A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer. iScience 23(9): 101496. DOI: 10.1016/j.isci.2020.101496
Chemical shifts-based similarity restraints improve accuracy of RNA structures determined via NMR.
Lawrence C, Grishaev A, Lawrence C, Grishaev A. 2020. Chemical shifts-based similarity restraints improve accuracy of RNA structures determined via NMR. RNA (New York, N.Y.) 26(12): 2051-2061. DOI: 10.1261/rna.074617.119
General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM.
Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA, Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA. 2020. General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proceedings of the National Academy of Sciences of the United States of America 117(39): 24269-24273. DOI: 10.1073/pnas.2009707117
CoV3D: a database of high resolution coronavirus protein structures.
Gowthaman R, Guest JD, Yin R, Adolf-Bryfogle J, Schief WR, Pierce BG, Gowthaman R, Guest JD, Yin R, Adolf-Bryfogle J, Schief WR, Pierce BG. 2021. CoV3D: a database of high resolution coronavirus protein structures. Nucleic acids research 49(D1): D282-D287. DOI: 10.1093/nar/gkaa731
Monitoring of the sedimentation kinetics of vaccine adjuvants using water proton NMR relaxation.
Taraban MB, Yu YB, Taraban MB, Yu YB. 2021. Monitoring of the sedimentation kinetics of vaccine adjuvants using water proton NMR relaxation. Magnetic resonance in chemistry : MRC 59(2): 147-161. DOI: 10.1002/mrc.5096
Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
Pierce BG, Keck ZY, Wang R, Lau P, Garagusi K, Elkholy K, Toth EA, Urbanowicz RA, Guest JD, Agnihotri P, et al. 2020. Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Journal of virology 94(22): . DOI: 10.1128/JVI.00704-20
Reducing the measurement time of exact NOEs by non-uniform sampling.
Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, Vögeli B, Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, Vögeli B. 2020. Reducing the measurement time of exact NOEs by non-uniform sampling. Journal of biomolecular NMR 74(12): 717-739. DOI: 10.1007/s10858-020-00344-8