Publications
Structural and biochemical insights into flavivirus proteins.
Dey D, Poudyal S, Rehman A, Hasan SS, Dey D, Poudyal S, Rehman A, Hasan SS. 2021. Structural and biochemical insights into flavivirus proteins. Virus research 296: 198343. DOI: 10.1016/j.virusres.2021.198343
Overexpression of two CDPKs from wild Chinese grapevine enhances powdery mildew resistance in Vitis vinifera and Arabidopsis.
Hu Y, Cheng Y, Yu X, Liu J, Yang L, Gao Y, Ke G, Zhou M, Mu B, Xiao S, et al. 2021. Overexpression of two CDPKs from wild Chinese grapevine enhances powdery mildew resistance in Vitis vinifera and Arabidopsis. The New phytologist 230(5): 2029-2046. DOI: 10.1111/nph.17285
Intracellular Delivery of Active Proteins by Polyphosphazene Polymers.
Qamar B, Solomon M, Marin A, Fuerst TR, Andrianov AK, Muro S, Qamar B, Solomon M, Marin A, Fuerst TR, Andrianov AK, Muro S. 2021. Intracellular Delivery of Active Proteins by Polyphosphazene Polymers. Pharmaceutics 13(2): . DOI: 10.3390/pharmaceutics13020249
Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP.
Valencia SM, Zacharia A, Marin A, Matthews RL, Wu CK, Myers B, Sanders C, Difilippantonio S, Kirnbauer R, Roden RB, et al. 2021. Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP. Human vaccines & immunotherapeutics 17(8): 2748-2761. DOI: 10.1080/21645515.2021.1875763
Grand Challenges in Pharmaceutical Research Series: Ridding the Cold Chain for Biologics.
Yu YB, Briggs KT, Taraban MB, Brinson RG, Marino JP, Yu YB, Briggs KT, Taraban MB, Brinson RG, Marino JP. 2021. Grand Challenges in Pharmaceutical Research Series: Ridding the Cold Chain for Biologics. Pharmaceutical research 38(1): 3-7. DOI: 10.1007/s11095-021-03008-w
Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization.
Wang Y, Howell KA, Brannan J, Agans KN, Turner HL, Wirchnianski AS, Kailasan S, Fusco M, Galkin A, Chiang CI, et al. 2021. Prominent Neutralizing Antibody Response Targeting the <i>Ebolavirus</i> Glycoprotein Subunit Interface Elicited by Immunization. Journal of virology : . DOI: 10.1128/JVI.01907-20
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants.
Guest JD, Vreven T, Zhou J, Moal I, Jeliazkov JR, Gray JJ, Weng Z, Pierce BG, Guest JD, Vreven T, Zhou J, Moal I, Jeliazkov JR, Gray JJ, Weng Z, Pierce BG. 2021. An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants. Structure (London, England : 1993) 29(6): 606-621.e5. DOI: 10.1016/j.str.2021.01.005
Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.
Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, et al. 2021. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. Scientific reports 11(1): 2751. DOI: 10.1038/s41598-021-81895-0
Application of bacteriophage-derived endolysins to combat streptococcal disease: current state and perspectives.
Linden SB, Alreja AB, Nelson DC, Linden SB, Alreja AB, Nelson DC. 2021. Application of bacteriophage-derived endolysins to combat streptococcal disease: current state and perspectives. Current opinion in biotechnology 68: 213-220. DOI: 10.1016/j.copbio.2021.01.012
Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine.
Marin A, Chowdhury A, Valencia SM, Zacharia A, Kirnbauer R, Roden RBS, Pinto LA, Shoemaker RH, Marshall JD, Andrianov AK, Marin A, Chowdhury A, Valencia SM, Zacharia A, Kirnbauer R, Roden RBS, Pinto LA, Shoemaker RH, Marshall JD, Andrianov AK. 2021. Next generation polyphosphazene immunoadjuvant: Synthesis, self-assembly and in vivo potency with human papillomavirus VLPs-based vaccine. Nanomedicine : nanotechnology, biology, and medicine 33: 102359. DOI: 10.1016/j.nano.2021.102359
Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS).
Young BD, Yu W, Rodríguez DJV, Varney KM, MacKerell AD, Weber DJ, Young BD, Yu W, Rodríguez DJV, Varney KM, MacKerell AD, Weber DJ. 2021. Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS). Molecules (Basel, Switzerland) 26(2): . DOI: 10.3390/molecules26020381
Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae.
Parvaiz N, Ahmad F, Yu W, MacKerell AD, Azam SS, Parvaiz N, Ahmad F, Yu W, MacKerell AD, Azam SS. 2021. Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae. PloS one 16(1): e0244967. DOI: 10.1371/journal.pone.0244967
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Guest JD, Wang R, Elkholy KH, Chagas A, Chao KL, Cleveland TE, Kim YC, Keck ZY, Marin A, Yunus AS, et al. 2021. Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer. Proceedings of the National Academy of Sciences of the United States of America 118(3): . DOI: 10.1073/pnas.2015149118
Creation and filtering of a recurrent spectral library of CHO cell metabolites and media components.
Telu KH, Marupaka R, Andriamaharavo NR, Simón-Manso Y, Liang Y, Mirokhin YA, Bukhari TH, Preston RJ, Kashi L, Kelman Z, et al. 2021. Creation and filtering of a recurrent spectral library of CHO cell metabolites and media components. Biotechnology and bioengineering 118(4): 1491-1510. DOI: 10.1002/bit.27661
Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint.
Solano-Gonzalez E, Coburn KM, Yu W, Wilson GM, Nurmemmedov E, Kesari S, Chang ET, MacKerell AD, Weber DJ, Carrier F, Solano-Gonzalez E, Coburn KM, Yu W, Wilson GM, Nurmemmedov E, Kesari S, Chang ET, MacKerell AD, Weber DJ, Carrier F. 2021. Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint. Nucleic acids research 49(3): 1235-1246. DOI: 10.1093/nar/gkaa1254
High-throughput modeling and scoring of TCR-pMHC complexes to predict cross-reactive peptides.
Borrman T, Pierce BG, Vreven T, Baker BM, Weng Z, Borrman T, Pierce BG, Vreven T, Baker BM, Weng Z. 2020. High-throughput modeling and scoring of TCR-pMHC complexes to predict cross-reactive peptides. Bioinformatics (Oxford, England) : . DOI: 10.1093/bioinformatics/btaa1050
Structural Characterization and Modeling of a Respiratory Syncytial Virus Fusion Glycoprotein Nanoparticle Vaccine in Solution.
Krueger S, Curtis JE, Scott DR, Grishaev A, Glenn G, Smith G, Ellingsworth L, Borisov O, Maynard EL, Krueger S, Curtis JE, Scott DR, Grishaev A, Glenn G, Smith G, Ellingsworth L, Borisov O, Maynard EL. 2021. Structural Characterization and Modeling of a Respiratory Syncytial Virus Fusion Glycoprotein Nanoparticle Vaccine in Solution. Molecular pharmaceutics 18(1): 359-376. DOI: 10.1021/acs.molpharmaceut.0c00986
Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings.
Albright V, Penarete-Acosta D, Stack M, Zheng J, Marin A, Hlushko H, Wang H, Jayaraman A, Andrianov AK, Sukhishvili SA, Albright V, Penarete-Acosta D, Stack M, Zheng J, Marin A, Hlushko H, Wang H, Jayaraman A, Andrianov AK, Sukhishvili SA. 2021. Polyphosphazenes enable durable, hemocompatible, highly efficient antibacterial coatings. Biomaterials 268: 120586. DOI: 10.1016/j.biomaterials.2020.120586
Sand Fly (Phlebotomus papatasi) Embryo Microinjection for CRISPR/Cas9 Mutagenesis.
Louradour I, Ghosh K, Inbar E, Sacks DL, Aluvihare C, Harrell RA, Louradour I, Ghosh K, Inbar E, Sacks DL, Aluvihare C, Harrell RA. 2020. Sand Fly (Phlebotomus papatasi) Embryo Microinjection for CRISPR/Cas9 Mutagenesis. Journal of visualized experiments : JoVE (165): . DOI: 10.3791/61924
Polyphosphazene immunoadjuvants: Historical perspective and recent advances.
Andrianov AK, Langer R, Andrianov AK, Langer R. 2021. Polyphosphazene immunoadjuvants: Historical perspective and recent advances. Journal of controlled release : official journal of the Controlled Release Society 329: 299-315. DOI: 10.1016/j.jconrel.2020.12.001